Ontology highlight
ABSTRACT:
SUBMITTER: Mehine M
PROVIDER: S-EPMC7766537 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Mehine Miika M Khamaiseh Sara S Ahvenainen Terhi T Heikkinen Tuomas T Äyräväinen Anna A Pakarinen Päivi P Härkki Päivi P Pasanen Annukka A Bützow Ralf R Vahteristo Pia P
Cancers 20201219 12
Uterine leiomyomas are benign smooth muscle tumors occurring in 70% of women of reproductive age. The majority of leiomyomas harbor one of three well-established genetic changes: a hotspot mutation in <i>MED12</i>, overexpression of <i>HMGA2</i>, or biallelic loss of <i>FH</i>. The majority of studies have classified leiomyomas by complex and costly methods, such as whole-genome sequencing, or by combining multiple traditional methods, such as immunohistochemistry and Sanger sequencing. The type ...[more]