Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol.
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ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC7767115 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol.
Yuan Xianghua X Liu Jing J Li Ruilian R Zhou Junlin J Wei Jinhua J Jiao Siming S Wang Zhuo A ZA Du Yuguang Y
Molecules (Basel, Switzerland) 20201221 24
The formation of bacterial biofilms has increased the resistance of bacteria to various environmental factors and is tightly associated with many persistent and chronic bacterial infections. Herein we design a strategy conjugating florfenicol, an antibiotic commonly used in the treatment of <i>streptococcus</i>, with the antimicrobial biomaterial, chitosan oligosaccharides. The results demonstrated that the florfenicol-COS conjugate (F-COS) efficiently eradicated the mature <i>Streptococcus hyov ...[more]
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