Ontology highlight
ABSTRACT:
SUBMITTER: Vrablicova Z
PROVIDER: S-EPMC7768081 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Vrablicova Zuzana Z Tomova Kristina K Tothova Lubomira L Babickova Janka J Gromova Barbora B Konecna Barbora B Liptak Robert R Hlavaty Tibor T Gardlik Roman R
Frontiers in medicine 20201214
<b>Background:</b> The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity in IBD patients in clinical remission. <b>Materials and Methods:</b> Plasma and serum were obtained from 72 patients with Crohn's disease and 28 patients with ulcerative colitis. Total cfDNA, nuclear DNA (ncDNA), mitochondrial DNA (mtDNA) and DNase activity were measu ...[more]