Ontology highlight
ABSTRACT:
SUBMITTER: Tang N
PROVIDER: S-EPMC7768441 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Tang Neos N Lu Chun-Yi CY Sue Shih-Che SC Chen Ting-Hsuan TH Jan Jia-Tsrong JT Huang Ming-Hsi MH Huang Chung-Hsiung CH Chen Chung-Chu CC Chiang Bor-Luen BL Huang Li-Min LM Wu Suh-Chin SC
Vaccines 20201130 4
Human infections with highly pathogenic avian influenza H5N1 viruses persist as a major global health concern. Vaccination remains the primary protective strategy against H5N1 and other novel avian influenza virus infections. We investigated the use of <i>E. coli</i> type IIb heat labile enterotoxin B subunit (LTIIb-B5) as a mucosal adjuvant for intranasal immunizations with recombinant HA proteins against H5N1 avian influenza viruses. Use of LTIIb-B5 adjuvant elicited more potent IgG, IgA, and ...[more]