Ontology highlight
ABSTRACT:
SUBMITTER: Shi B
PROVIDER: S-EPMC7770554 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Shi Bo B Wang Wenxia W Korman Benjamin B Kai Li L Wang Qianqian Q Wei Jun J Bale Swarna S Marangoni Roberta Goncalves RG Bhattacharyya Swati S Miller Stephen S Xu Dan D Akbarpour Mahzad M Cheresh Paul P Proccissi Daniele D Gursel Demirkan D Espindola-Netto Jair Machado JM Chini Claudia C S CCS de Oliveira Guilherme C GC Gudjonsson Johann E JE Chini Eduardo N EN Varga John J
iScience 20201207 1
The processes underlying synchronous multiple organ fibrosis in systemic sclerosis (SSc) remain poorly understood. Age-related pathologies are associated with organismal decline in nicotinamide adenine dinucleotide (NAD<sup>+</sup>) that is due to dysregulation of NAD<sup>+</sup> homeostasis and involves the NADase CD38. We now show that CD38 is upregulated in patients with diffuse cutaneous SSc, and CD38 levels in the skin associate with molecular fibrosis signatures, as well as clinical fibros ...[more]