Ontology highlight
ABSTRACT:
SUBMITTER: Roome CJ
PROVIDER: S-EPMC7771959 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Roome Christopher J CJ Kuhn Bernd B
eLife 20201221
Dendritic coincidence detection is fundamental to neuronal processing yet remains largely unexplored in awake animals. Specifically, the underlying dendritic voltage-calcium relationship has not been directly addressed. Here, using simultaneous voltage and calcium two-photon imaging of Purkinje neuron spiny dendrites, we show how coincident synaptic inputs and resulting dendritic spikes modulate dendritic calcium signaling during sensory stimulation in awake mice. Sensory stimulation increased t ...[more]