Ontology highlight
ABSTRACT:
SUBMITTER: Najafi F
PROVIDER: S-EPMC3996650 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Najafi Farzaneh F Giovannucci Andrea A Wang Samuel S-H SS Medina Javier F JF
Cell reports 20140227 5
Climbing fibers (CFs) are thought to contribute to cerebellar plasticity and learning by triggering a large influx of dendritic calcium in the postsynaptic Purkinje cell (PC) to signal the occurrence of an unexpected sensory event. However, CFs fire about once per second whether or not an event occurs, raising the question of how sensory-driven signals might be distinguished from a background of ongoing spontaneous activity. Here, we report that in PC dendrites of awake mice, CF-triggered calciu ...[more]