Dataset Information

Simultaneous Mapping of T₁ and T₂ Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T.

ABSTRACT:

Background

Cardiac MR fingerprinting (cMRF) is a novel technique for simultaneous T₁ and T₂ mapping.

Purpose

To compare T₁ /T₂ measurements, repeatability, and map quality between cMRF and standard mapping techniques in healthy subjects.

Study type

Prospective.

Population

In all, 58 subjects (ages 18-60). FIELD STRENGTH/SEQUENCE: cMRF, modified Look-Locker inversion recovery (MOLLI), and T₂ -prepared balanced steady-state free precession (bSSFP) at 1.5T.

Assessment

T₁ /T₂ values were measured in 16 myocardial segments at apical, medial, and basal slice positions. Test-retest and intrareader repeatability were assessed for the medial slice. cMRF and conventional mapping sequences were compared using ordinal and two alternative forced choice (2AFC) ratings.

Statistical tests

Paired t-tests, Bland-Altman analyses, intraclass correlation coefficient (ICC), linear regression, one-way analysis of variance (ANOVA), and binomial tests.

Results

Average T₁ measurements were: basal 1007.4±96.5 msec (cMRF), 990.0±45.3 msec (MOLLI); medial 995.0±101.7 msec (cMRF), 995.6±59.7 msec (MOLLI); apical 1006.6±111.2 msec (cMRF); and 981.6±87.6 msec (MOLLI). Average T₂ measurements were: basal 40.9±7.0 msec (cMRF), 46.1±3.5 msec (bSSFP); medial 41.0±6.4 msec (cMRF), 47.4±4.1 msec (bSSFP); apical 43.5±6.7 msec (cMRF), 48.0±4.0 msec (bSSFP). A statistically significant bias (cMRF T₁ larger than MOLLI T₁ ) was observed in basal (17.4 msec) and apical (25.0 msec) slices. For T₂ , a statistically significant bias (cMRF lower than bSSFP) was observed for basal (-5.2 msec), medial (-6.3 msec), and apical (-4.5 msec) slices. Precision was lower for cMRF-the average of the standard deviation measured within each slice was 102 msec for cMRF vs. 61 msec for MOLLI T₁ , and 6.4 msec for cMRF vs. 4.0 msec for bSSFP T₂ . cMRF and conventional techniques had similar test-retest repeatability as quantified by ICC (0.87 cMRF vs. 0.84 MOLLI for T₁ ; 0.85 cMRF vs. 0.85 bSSFP for T₂ ). In the ordinal image quality comparison, cMRF maps scored higher than conventional sequences for both T₁ (all five features) and T₂ (four features).

Data conclusion

This work reports on myocardial T₁ /T₂ measurements in healthy subjects using cMRF and standard mapping sequences. cMRF had slightly lower precision, similar test-retest and intrareader repeatability, and higher scores for map quality.

Evidence level

2 TECHNICAL EFFICACY: Stage 1 J. Magn. Reson. Imaging 2020;52:1044-1052.

SUBMITTER: Hamilton JI

PROVIDER: S-EPMC7772954 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:PURPOSE:Cardiac magnetic resonance fingerprinting (cMRF) has been recently introduced to simultaneously provide T1 , T2 , and M0 maps. Here, we develop a 3-point Dixon-cMRF approach to enable simultaneous water specific T1 , T2 , and M0 mapping of the heart and fat fraction (FF) estimation in a single breath-hold scan. METHODS:Dixon-cMRF is achieved by combining cMRF with several innovations that were previously introduced for other applications, including a 3-echo GRE acquisition with golden angle radial readout and a high-dimensional low-rank tensor constrained reconstruction to recover the highly undersampled time series images for each echo. Water-fat separation of the Dixon-cMRF time series is performed to allow for water- and fat-specific T1 , T2 , and M0 estimation, whereas FF estimation is extracted from the M0 maps. Dixon-cMRF was evaluated in a standardized T1 -T2 phantom, in a water-fat phantom, and in healthy subjects in comparison to current clinical standards: MOLLI, SASHA, T2 -GRASE, and 6-point Dixon proton density FF (PDFF) mapping. RESULTS:Dixon-cMRF water T1 and T2 maps showed good agreement with reference T1 and T2 mapping techniques (R2 > 0.99 and maximum normalized RMSE ~5%) in a standardized phantom. Good agreement was also observed between Dixon-cMRF FF and reference PDFF (R2 > 0.99) and between Dixon-cMRF water T1 and T2 and water selective T1 and T2 maps (R2 > 0.99) in a water-fat phantom. In vivo Dixon-cMRF water T1 values were in good agreement with MOLLI and water T2 values were slightly underestimated when compared to T2 -GRASE. Average myocardium septal T1 values were 1129 ± 38 ms, 1026 ± 28 ms, and 1045 ± 32 ms for SASHA, MOLLI, and the proposed water Dixon-cMRF. Average T2 values were 51.7 ± 2.2 ms and 42.8 ± 2.6 ms for T2 -GRASE and water Dixon-cMRF, respectively. Dixon-cMRF FF maps showed good agreement with in vivo PDFF measurements (R2 > 0.98) and average FF in the septum was measured at 1.3%. CONCLUSION:The proposed Dixon-cMRF allows to simultaneously quantify myocardial water T1 , water T2 , and FF in a single breath-hold scan, enabling multi-parametric T1 , T2 , and fat characterization. Moreover, reduced T1 and T2 quantification bias caused by water-fat partial volume was demonstrated in phantom experiments.

Project description:BackgroundQuantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging.PurposeTo introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time.Study typeReproducibility, technical validation.Subjects/phantomA seven-compartment phantom and three healthy volunteers.Field strength/sequenceA novel MR pulse sequence that simultaneously measures proton density (PD), T1 , and T2 at 3 T was developed. Automatic positioning and semiautomatic cartilage segmentation were implemented to improve consistency and simplify workflow.AssessmentIntra- and interscanner variability of our technique was assessed over multiple scans on three different MR scanners.Statistical testsFor each scan, the median of cartilage T1 and T2 over six radial slices was calculated. Restricted maximum likelihood estimation of variance components was used to estimate intrasubject variances reflecting variation between results from the two scans using the same scanner (intrascanner variance) and variation among results from the three scanners (interscanner variance).ResultsThe estimation error for T1 and T2 with respect to reference standard measurements was less than 3% on average for the phantom. The average interscanner coefficient of variation was 1.5% (1.2-1.9%) and 0.9% (0.0-3.7%) for T1 and T2 , respectively, in the seven compartments of the phantom. Total scan time in vivo was 7:13 minutes to obtain PD, T1 , and T2 maps along six radial hip sections at 0.6 × 0.6 × 4.0 mm3 voxel resolution. Interscanner variability for the in vivo study was 1.99% and 5.46% for T1 and T2 , respectively. in vivo intrascanner variability was 1.15% for T1 and 3.24% for T2 .Data conclusionOur method, which includes slice positioning, model-based parameter estimation, and cartilage segmentation, is highly reproducible. It could enable employing quantitative hip cartilage evaluation for longitudinal and multicenter studies.Level of evidence1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:810-815.

Dataset Information

Simultaneous Mapping of T₁ and T₂ Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T.

Background

Purpose

Study type

Population

Assessment

Statistical tests

Results

Data conclusion

Evidence level

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Simultaneous Mapping of T1 and T2 Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T.

Background

Purpose

Study type

Population

Assessment

Statistical tests

Results

Data conclusion

Evidence level

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Simultaneous Mapping of T₁ and T₂ Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T.