Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC7773145 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zhang Siwei S Zhang Hanwen H Zhou Yifan Y Qiao Min M Zhao Siming S Kozlova Alena A Shi Jianxin J Sanders Alan R AR Wang Gao G Luo Kaixuan K Sengupta Subhajit S West Siobhan S Qian Sheng S Streit Michael M Avramopoulos Dimitrios D Cowan Chad A CA Chen Mengjie M Pang Zhiping P ZP Gejman Pablo V PV He Xin X Duan Jubao J
Science (New York, N.Y.) 20200701 6503
Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional interpretation. Because regulatory sequences often reside in open chromatin, we reasoned that neuropsychiatric disease risk variants may affect chromatin accessibility during neurodevelopment. Using human induced pluripotent stem cell (iPSC)-derived neurons that model developing brains, we identified thousands of genetic variants exhibiting allele-specific open chromatin (ASoC). These neuronal ASoCs were p ...[more]