Enhanced gamma band mutual information is associated with impaired consciousness during temporal lobe seizures.
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ABSTRACT: Background
Epileptic seizures are characterized by aberrant synchronization. We hypothesized that higher synchronization across the seizure onset zone (SOZ) channels during a temporal lobe seizure contributes to impaired consciousness.New method
All symmetric bivariate synchronization measures were extended to multivariate measure by a principal component analysis (PCA) based technique. A novel nonparametric method has been proposed to test the statistical significance between increased synchronization across the seizure onset zone (SOZ) channels and reduced consciousness.Results
Increased synchronization in the gamma band towards seizure termination significantly contributes to impaired consciousness (p < 0.1). Synchronization reaches its peak in the extratemporal region (frontal lobe) ahead of the temporal region (p < 0.05). Synchronization is prominent in beta and gamma bands by most methods and it is more in the second half of seizure duration than in the first (p < 0.05).Conclusions
Mutual information is the only synchronization measure out of the six that we studied, whose increase can be associated with the loss of consciousness in a statistically significant way.
SUBMITTER: Dheer P
PROVIDER: S-EPMC7773881 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Enhanced gamma band mutual information is associated with impaired consciousness during temporal lobe seizures.
Dheer Puneet P Pati Sandipan S Chowdhury Kalyan Kumar KK Majumdar Kaushik Kumar KK
Heliyon 20201223 12
<h4>Background</h4>Epileptic seizures are characterized by aberrant synchronization. We hypothesized that higher synchronization across the seizure onset zone (SOZ) channels during a temporal lobe seizure contributes to impaired consciousness.<h4>New method</h4>All symmetric bivariate synchronization measures were extended to multivariate measure by a principal component analysis (PCA) based technique. A novel nonparametric method has been proposed to test the statistical significance between in ...[more]
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