Ontology highlight
ABSTRACT:
SUBMITTER: Symonds AC
PROVIDER: S-EPMC7774892 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Symonds Andrew C AC Buckley Clare E CE Williams Charlotte A CA Clarke Jonathan D W JDW
Development (Cambridge, England) 20201223 24
Using the zebrafish neural tube as a model, we uncover the <i>in vivo</i> mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We show that Mpp5a and Rab11a play a dual role in coordinating the generation of ipsilateral junctional belts whilst simultaneously releasing contralateral adhesions across the centre of the tissue. We show that Mpp5a- and Rab11a-mediated resolution of cell-cell adhesions are both necess ...[more]