Dataset Information

Repeatability and reproducibility of human brain morphometry using three-dimensional magnetic resonance fingerprinting.

ABSTRACT: Three-dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole-brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1-weighted structural imaging for common brain imaging analysis. The aim of this study was to evaluate the repeatability and reproducibility of 3D MRF in evaluating brain cortical thickness and subcortical volumetric analysis in healthy volunteers using conventional 3D T1-weighted images as a reference standard. Scan-rescan tests of both 3D MRF and conventional 3D fast spoiled gradient recalled echo (FSPGR) were performed. For each sequence, the regional cortical thickness and volume of the subcortical structures were measured using standard automatic brain segmentation software. Repeatability and reproducibility were assessed using the within-subject coefficient of variation (wCV), intraclass correlation coefficient (ICC), and mean percent difference and ICC, respectively. The wCV and ICC of cortical thickness were similar across all regions with both 3D MRF and FSPGR. The percent relative difference in cortical thickness between 3D MRF and FSPGR across all regions was 8.0?±?3.2%. The wCV and ICC of the volume of subcortical structures across all structures were similar between 3D MRF and FSPGR. The percent relative difference in the volume of subcortical structures between 3D MRF and FSPGR across all structures was 7.1?±?3.6%. 3D MRF measurements of human brain cortical thickness and subcortical volumes are highly repeatable, and consistent with measurements taken on conventional 3D T1-weighted images. A slight, consistent bias was evident between the two, and thus careful attention is required when combining data from MRF and conventional acquisitions.

SUBMITTER: Fujita S

PROVIDER: S-EPMC7775993 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Repeatability and reproducibility of human brain morphometry using three-dimensional magnetic resonance fingerprinting.

Fujita Shohei S Buonincontri Guido G Cencini Matteo M Fukunaga Issei I Takei Naoyuki N Schulte Rolf F RF Hagiwara Akifumi A Uchida Wataru W Hori Masaaki M Kamagata Koji K Abe Osamu O Aoki Shigeki S

Human brain mapping 20201022 2

Three-dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole-brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1-weighted structural imaging for common brain imaging analysis. The aim of this study was to evaluate the repeatability and reproducibility of 3D MRF in evaluating brain cortical thickness and subcortical volumetric analysis in healthy volunteers using conventional 3D T1-weighted images as a reference standard. Scan-resc ...[more]

PMID: 33089962

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Project description:ObjectivesWe aimed to investigate the influence of magnetic resonance fingerprinting (MRF) dictionary design on radiomic features using in vivo human brain scans.MethodsScan-rescans of three-dimensional MRF and conventional T1-weighted imaging were performed on 21 healthy volunteers (9 males and 12 females; mean age, 41.3 ± 14.6 years; age range, 22-72 years). Five patients with multiple sclerosis (3 males and 2 females; mean age, 41.2 ± 7.3 years; age range, 32-53 years) were also included. MRF data were reconstructed using various dictionaries with different step sizes. First- and second-order radiomic features were extracted from each dataset. Intra-dictionary repeatability and inter-dictionary reproducibility were evaluated using intraclass correlation coefficients (ICCs). Features with ICCs > 0.90 were considered acceptable. Relative changes were calculated to assess inter-dictionary biases.ResultsThe overall scan-rescan ICCs of MRF-based radiomics ranged from 0.86 to 0.95, depending on dictionary step size. No significant differences were observed in the overall scan-rescan repeatability of MRF-based radiomic features and conventional T1-weighted imaging (p = 1.00). Intra-dictionary repeatability was insensitive to dictionary step size differences. MRF-based radiomic features varied among dictionaries (overall ICC for inter-dictionary reproducibility, 0.62-0.99), especially when step sizes were large. First-order and gray level co-occurrence matrix features were the most reproducible feature classes among different step size dictionaries. T1 map-derived radiomic features provided higher repeatability and reproducibility among dictionaries than those obtained with T2 maps.ConclusionMRF-based radiomic features are highly repeatable in various dictionary step sizes. Caution is warranted when performing MRF-based radiomics using datasets containing maps generated from different dictionaries.Key points• MRF-based radiomic features are highly repeatable in various dictionary step sizes. • Use of different MRF dictionaries may result in variable radiomic features, even when the same MRF acquisition data are used. • Caution is needed when performing radiomic analysis using data reconstructed from different dictionaries.

Project description:PurposeTo compare the bias and inherent reliability of the quantitative (T1 and T2 ) imaging metrics generated from the magnetic resonance fingerprinting (MRF) technique using the ISMRM/NIST system phantom in an international multicenter setting.MethodISMRM/NIST MRI system phantom provides standard reference T1 and T2 relaxation values (vendor-provided) for each of the 14 vials in T1 and T2 arrays. MRF-SSFP scans repeated over 30 days on GE 1.5 and 3.0 T scanners at three collaborative centers. MRF estimated T1, and T2 values averaged over 30 days were compared with the phantom vendor-provided and spin-echo (SE) based convention gold standard (GS) method. Repeatability and reproducibility were characterized by the within-case coefficient of variation (wCV) of the MRF data acquired over 30 days, along with the biases.ResultFor the wide ranges of MRF estimated T1 values, vials #1-8 (T1 relaxation time between 2033 and 184 ms) exhibited a wCV less than 3% and 4%, respectively, on 3.0 and 1.5 T scanners. T2 values in vials #1-8 (T2 relaxation, 1044-45 ms) have shown wCV to be <7% on both 3.0 and 1.5 T scanners. A stronger linear correlation overall for T1 (R2 = 0.9960 and 0.9963 at center-1 and center-2 on 3.0 T scanner, and R2 = 0.9951 and 0.9988 at center-1 and center-3 on 1.5 T scanner) compared to T2 (R2 = 0.9971 and 0.9972 at center-1 and center-2 on 3.0 T scanner, and R2 = 0.9815 and 0.9754 at center-1 and center-3 on 1.5 T scanner). Bland-Altman (BA) analysis showed MRF based T1 and T2 values were within the limit of agreement (LOA) except for one data point. The mean difference or bias and 95% lower bound (LB) and upper bound (UB) LOA are reported in the format; mean bias: 95% LB LOA: 95% UB LOA. The biases for T1 values were 21.34: -50.00: 92.69, 21.32: -47.29: 89.94 ms, and for T2 values were -19.88: -42.37: 2.61, -19.06: -43.58: 5.45 ms on 3.0 T scanner at center-1 and center-2, respectively. Similarly, on 1.5 T scanner biases for T1 values were 26.54: -53.41: 106.50, 9.997: -51.94: 71.94 ms, and for T2 values were -23.84: -135.40: 87.76, -37.30: 134.30: 59.73 ms at center-1 and center-3, respectively. Additionally, the correlation between the SE based GS and MRF estimated T1 and T2 values (R2 = 0.9969 and 0.9977) showed a similar trend as we observed between vendor-provided and MRF estimated T1 and T2 values (R2 = 0.9963 and 0.9972). In addition to correlation, BA analysis showed that all the vials are within the LOA between the GS and vendor-provided for the T1 values and except one vial for T2 . All the vials are within the LOA between GS and MRF except one vial in T1 and T2 array. The wCV for reproducibility was <3% for both T1 and T2 values in vials #1-8, for all the 14 vials, wCV calculated for reproducibility was <4% for T1 values and <5% for T2 .ConclusionThis study shows that MRF is highly repeatable (wCV <4% for T1 and <7% for T2 ) and reproducible (wCV < 3% for both T1 and T2 ) in certain vials (vials #1-8).

Project description:ObjectivesTo assess the accuracy, repeatability, and reproducibility of T1 and T2 relaxation time measurements by three-dimensional magnetic resonance fingerprinting (3D MRF) using various dictionary resolutions.MethodsThe ISMRM/NIST phantom was scanned daily for 10 days in two 3 T MR scanners using a 3D MRF sequence reconstructed using four dictionaries with varying step sizes and one dictionary with wider ranges. Thirty-nine healthy volunteers were enrolled: 20 subjects underwent whole-brain MRF scans in both scanners and the rest in one scanner. ROI/VOI analyses were performed on phantom and brain MRF maps. Accuracy, repeatability, and reproducibility metrics were calculated.ResultsIn the phantom study, all dictionaries showed high T1 linearity to the reference values (R2 > 0.99), repeatability (CV < 3%), and reproducibility (CV < 3%) with lower linearity (R2 > 0.98), repeatability (CV < 6%), and reproducibility (CV ≤ 4%) for T2 measurement. The volunteer study demonstrated high T1 reproducibility of within-subject CV (wCV) < 4% by all dictionaries with the same ranges, both in the brain parenchyma and CSF. Yet, reproducibility was moderate for T2 measurement (wCV < 8%). In CSF measurement, dictionaries with a smaller range showed a seemingly better reproducibility (T1, wCV 3%; T2, wCV 8%) than the much wider range dictionary (T1, wCV 5%; T2, wCV 13%). Truncated CSF relaxometry values were evident in smaller range dictionaries.ConclusionsThe accuracy, repeatability, and reproducibility of 3D MRF across various dictionary resolutions were high for T1 and moderate for T2 measurements. A lower-resolution dictionary with a well-defined range may be adequate, thus significantly reducing the computational load.Key points• A lower-resolution dictionary with a well-defined range may be sufficient for 3D MRF reconstruction. • CSF relaxation times might be underestimated due to truncation by the upper dictionary range. • Dictionary with a higher upper range might be advisable, especially for CSF evaluation and elderly subjects whose perivascular spaces are more prominent.

Dataset Information

Repeatability and reproducibility of human brain morphometry using three-dimensional magnetic resonance fingerprinting.

Publications

Repeatability and reproducibility of human brain morphometry using three-dimensional magnetic resonance fingerprinting.

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