Dataset Information

Accuracy, repeatability, and reproducibility of T₁ and T₂ relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.

ABSTRACT:

Objectives

To assess the accuracy, repeatability, and reproducibility of T₁ and T₂ relaxation time measurements by three-dimensional magnetic resonance fingerprinting (3D MRF) using various dictionary resolutions.

Methods

The ISMRM/NIST phantom was scanned daily for 10 days in two 3 T MR scanners using a 3D MRF sequence reconstructed using four dictionaries with varying step sizes and one dictionary with wider ranges. Thirty-nine healthy volunteers were enrolled: 20 subjects underwent whole-brain MRF scans in both scanners and the rest in one scanner. ROI/VOI analyses were performed on phantom and brain MRF maps. Accuracy, repeatability, and reproducibility metrics were calculated.

Results

In the phantom study, all dictionaries showed high T₁ linearity to the reference values (R² > 0.99), repeatability (CV < 3%), and reproducibility (CV < 3%) with lower linearity (R² > 0.98), repeatability (CV < 6%), and reproducibility (CV ≤ 4%) for T₂ measurement. The volunteer study demonstrated high T₁ reproducibility of within-subject CV (wCV) < 4% by all dictionaries with the same ranges, both in the brain parenchyma and CSF. Yet, reproducibility was moderate for T₂ measurement (wCV < 8%). In CSF measurement, dictionaries with a smaller range showed a seemingly better reproducibility (T₁, wCV 3%; T₂, wCV 8%) than the much wider range dictionary (T₁, wCV 5%; T₂, wCV 13%). Truncated CSF relaxometry values were evident in smaller range dictionaries.

Conclusions

The accuracy, repeatability, and reproducibility of 3D MRF across various dictionary resolutions were high for T₁ and moderate for T₂ measurements. A lower-resolution dictionary with a well-defined range may be adequate, thus significantly reducing the computational load.

Key points

• A lower-resolution dictionary with a well-defined range may be sufficient for 3D MRF reconstruction. • CSF relaxation times might be underestimated due to truncation by the upper dictionary range. • Dictionary with a higher upper range might be advisable, especially for CSF evaluation and elderly subjects whose perivascular spaces are more prominent.

SUBMITTER: Wicaksono KP

PROVIDER: S-EPMC10017611 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Accuracy, repeatability, and reproducibility of T<sub>1</sub> and T<sub>2</sub> relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.

Wicaksono Krishna Pandu KP Fushimi Yasutaka Y Nakajima Satoshi S Sakata Akihiko A Okuchi Sachi S Hinoda Takuya T Oshima Sonoko S Otani Sayo S Tagawa Hiroshi H Urushibata Yuta Y Nakamoto Yuji Y

European radiology 20221124 4

<h4>Objectives</h4>To assess the accuracy, repeatability, and reproducibility of T<sub>1</sub> and T<sub>2</sub> relaxation time measurements by three-dimensional magnetic resonance fingerprinting (3D MRF) using various dictionary resolutions.<h4>Methods</h4>The ISMRM/NIST phantom was scanned daily for 10 days in two 3 T MR scanners using a 3D MRF sequence reconstructed using four dictionaries with varying step sizes and one dictionary with wider ranges. Thirty-nine healthy volunteers were enrol ...[more]

PMID: 36422648

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Dataset Information

Accuracy, repeatability, and reproducibility of T₁ and T₂ relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.

Objectives

Methods

Results

Conclusions

Key points

Publications

Accuracy, repeatability, and reproducibility of T<sub>1</sub> and T<sub>2</sub> relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Accuracy, repeatability, and reproducibility of T1 and T2 relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.

Objectives

Methods

Results

Conclusions

Key points

Publications

Accuracy, repeatability, and reproducibility of T<sub>1</sub> and T<sub>2</sub> relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Accuracy, repeatability, and reproducibility of T₁ and T₂ relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions.