Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.
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ABSTRACT:
SUBMITTER: Madden SK
PROVIDER: S-EPMC7780693 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.
Madden Sarah K SK de Araujo Aline Dantas AD Gerhardt Mara M Fairlie David P DP Mason Jody M JM
Molecular cancer 20210104 1
c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this to be a viable therapeutic strategy. Here we reassess the challenges of directly targeting c-Myc, evaluate lessons learned from current inhibitors, and explore how future strategies such as miniaturisation of Omomyc and targeting E-box binding c ...[more]
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