Ontology highlight
ABSTRACT:
SUBMITTER: Horiuchi D
PROVIDER: S-EPMC4892842 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Horiuchi Dai D Anderton Brittany B Goga Andrei A
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 20140101
The transcription factor proto-oncogene c-MYC (hereafter MYC) was first identified more than 3 decades ago and has since been found deregulated in a wide variety of the most aggressive human malignancies. As a pleiotropic transcription factor, MYC directly or indirectly controls expression of hundreds of coding and noncoding genes, which affect cell cycle entry, proliferation, differentiation, metabolism, and death/survival decisions of normal and cancer cells. Tumors with elevated MYC expressio ...[more]