Ontology highlight
ABSTRACT:
SUBMITTER: Jamann N
PROVIDER: S-EPMC7782484 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Jamann Nora N Dannehl Dominik D Lehmann Nadja N Wagener Robin R Thielemann Corinna C Schultz Christian C Staiger Jochen J Kole Maarten H P MHP Engelhardt Maren M
Nature communications 20210104 1
The axon initial segment (AIS) is a critical microdomain for action potential initiation and implicated in the regulation of neuronal excitability during activity-dependent plasticity. While structural AIS plasticity has been suggested to fine-tune neuronal activity when network states change, whether it acts in vivo as a homeostatic regulatory mechanism in behaviorally relevant contexts remains poorly understood. Using the mouse whisker-to-barrel pathway as a model system in combination with im ...[more]