Ontology highlight
ABSTRACT:
SUBMITTER: Jagga B
PROVIDER: S-EPMC7782513 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Jagga Bikshapathi B Edwards Megan M Pagin Miriam M Wagstaff Kylie M KM Aragão David D Roman Noelia N Nanson Jeffrey D JD Raidal Shane R SR Dominado Nicole N Stewart Murray M Jans David A DA Hime Gary R GR Nicolis Silvia K SK Basler Christopher F CF Forwood Jade K JK
Nature communications 20210104 1
SOX (SRY-related HMG-box) transcription factors perform critical functions in development and cell differentiation. These roles depend on precise nuclear trafficking, with mutations in the nuclear targeting regions causing developmental diseases and a range of cancers. SOX protein nuclear localization is proposed to be mediated by two nuclear localization signals (NLSs) positioned within the extremities of the DNA-binding HMG-box domain and, although mutations within either cause disease, the me ...[more]