Ontology highlight
ABSTRACT:
SUBMITTER: Albertini M
PROVIDER: S-EPMC2132971 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
Albertini M M Pemberton L F LF Rosenblum J S JS Blobel G G
The Journal of cell biology 19981201 6
We have identified a novel pathway for protein import into the nucleus. We have shown that the previously identified but uncharacterized yeast protein Nmd5p functions as a karyopherin. It was therefore designated Kap119p (karyopherin with Mr of 119 kD). We localized Kap119p to both the nucleus and the cytoplasm. We identified the transcription elongation factor TFIIS as its major cognate import substrate. The cytoplasmic Kap119p exists as an approximately stoichiometric complex with TFIIS. RanGT ...[more]