Ontology highlight
ABSTRACT:
SUBMITTER: Ashby DM
PROVIDER: S-EPMC7782827 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Ashby Donovan M DM Floresco Stan B SB Phillips Anthony G AG McGirr Alexander A Seamans Jeremy K JK Wang Yu Tian YT
Nature communications 20210104 1
Hippocampal synaptic plasticity includes both long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength, and has been implicated in shaping place field representations that form upon initial exposure to a novel environment. However, direct evidence causally linking either LTP or LTD to place fields remains limited. Here, we show that hippocampal LTD regulates the acute formation and maintenance of place fields using electrophysiology and blocking specifically LTD in freely ...[more]