Designing a conserved peptide-based subunit vaccine against SARS-CoV-2 using immunoinformatics approach.

ABSTRACT: The widespread of coronavirus (COVID-19) is a new global health crisis that poses a threat to the world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in bats and was discovered first in Wuhan, Hubei province, China in December 2019. Immunoinformatics and bioinformatics tools were employed for the construction of a multi-epitope subunit vaccine to prevent the diseases. The antigenicity, toxicity and allergenicity of all epitopes used in the construction of the vaccine were predicted and then conjugated with adjuvants and linkers. Vaccine Toll-Like Receptors (2, 3, 4, 8 and 9) complex was also evaluated. The vaccine construct was antigenic, non-toxic and non-allergic, which indicates the vaccines ability to induce antibodies in the host, making it an effective vaccine candidate.

Supplementary information

The online version contains supplementary material available at 10.1007/s40203-020-00062-x.

SUBMITTER: Oladipo EK 

PROVIDER: S-EPMC7785481 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature