Long-term exposure to particulate matter and roadway proximity with age at natural menopause in the Nurses' Health Study II Cohort.

ABSTRACT: Evidence has shown associations between air pollution and traffic-related exposure with accelerated aging, but no study to date has linked the exposure with age at natural menopause, an important indicator of reproductive aging. In this study, we sought to examine the associations of residential exposure to ambient particulate matter (PM) and distance to major roadways with age at natural menopause in the Nurses' Health Study II (NHS II), a large, prospective female cohort in US. A total of 105,996 premenopausal participants in NHS II were included at age 40 and followed through 2015. Time-varying residential exposures to PM₁₀, PM_2.5-10, and PM_2.5 and distance to roads was estimated. We calculated hazard ratios (HR) and 95% confidence intervals (CIs) for na

SUBMITTER: Li H 

PROVIDER: S-EPMC7785633 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature