Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.
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ABSTRACT: Impact statement
Despite increasing evidence implicating the important role of TDP-43 in the pathogenesis of a wide range of age-related neurodegenerative diseases, there is limited study of TDP-43 proteinopathy and its association with mitochondria during normal aging. Our findings of cytoplasmic accumulation of TDP-43 that is highly colocalized with mitochondria in neurons in selective brain regions in young animals in the absence of neuronal loss provide a novel insight into the development of TDP-43 proteinopathy and its contribution to neuronal loss.
SUBMITTER: Termsarasab P
PROVIDER: S-EPMC7787547 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.
Termsarasab Pichet P Thammongkolchai Thananan T Gao Ju J Wang Luwen L Liang Jingjing J Wang Xinglong X
Experimental biology and medicine (Maywood, N.J.) 20200325 17
<h4>Impact statement</h4>Despite increasing evidence implicating the important role of TDP-43 in the pathogenesis of a wide range of age-related neurodegenerative diseases, there is limited study of TDP-43 proteinopathy and its association with mitochondria during normal aging. Our findings of cytoplasmic accumulation of TDP-43 that is highly colocalized with mitochondria in neurons in selective brain regions in young animals in the absence of neuronal loss provide a novel insight into the devel ...[more]
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