Ontology highlight
ABSTRACT:
SUBMITTER: Crowley C
PROVIDER: S-EPMC7788093 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Crowley Cheynna C Yang Yuchen Y Qiu Yunjiang Y Hu Benxia B Abnousi Armen A Lipiński Jakub J Plewczyński Dariusz D Wu Di D Won Hyejung H Ren Bing B Hu Ming M Li Yun Y
Computational and structural biotechnology journal 20201229
Hi-C experiments have been widely adopted to study chromatin spatial organization, which plays an essential role in genome function. We have recently identified frequently interacting regions (FIREs) and found that they are closely associated with cell-type-specific gene regulation. However, computational tools for detecting FIREs from Hi-C data are still lacking. In this work, we present FIREcaller, a stand-alone, user-friendly R package for detecting FIREs from Hi-C data. FIREcaller takes raw ...[more]