Dataset Information

Ultraprotective ventilation allowed by extracorporeal CO₂ removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study.

ABSTRACT:

Background

Right ventricular (RV) failure is a common complication in moderate-to-severe acute respiratory distress syndrome (ARDS). RV failure is exacerbated by hypercapnic acidosis and overdistension induced by mechanical ventilation. Veno-venous extracorporeal CO₂ removal (ECCO₂R) might allow ultraprotective ventilation with lower tidal volume (V_T) and plateau pressure (P_plat). This study investigated whether ECCO₂R therapy could affect RV function.

Methods

This was a quasi-experimental prospective observational pilot study performed in a French medical ICU. Patients with moderate-to-severe ARDS with PaO₂/FiO₂ ratio between 80 and 150 mmHg were enrolled. An ultraprotective ventilation strategy was used with V_T at 4 mL/kg of predicted body weight during the 24 h following the start of a low-flow ECCO₂R device. RV function was assessed by transthoracic echocardiography (TTE) during the study protocol.

Results

The efficacy of ECCO₂R facilitated an ultraprotective strategy in all 18 patients included. We observed a significant improvement in RV systolic function parameters. Tricuspid annular plane systolic excursion (TAPSE) increased significantly under ultraprotective ventilation compared to baseline (from 22.8 to 25.4 mm; p?ConclusionLow-flow ECCO₂R facilitates an ultraprotective ventilation strategy thatwould improve RV function in moderate-to-severe ARDS patients. Improvement in RV contractility appears to be mainly due to a decrease in intrathoracic pressure allowed by ultraprotective ventilation, rather than a reduction of PaCO₂.

SUBMITTER: Goursaud S

PROVIDER: S-EPMC7788545 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Ultraprotective ventilation allowed by extracorporeal CO2 removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study.

Goursaud Suzanne S Valette Xavier X Dupeyrat Julien J Daubin Cédric C du Cheyron Damien D

Annals of intensive care 20210107 1

<h4>Background</h4>Right ventricular (RV) failure is a common complication in moderate-to-severe acute respiratory distress syndrome (ARDS). RV failure is exacerbated by hypercapnic acidosis and overdistension induced by mechanical ventilation. Veno-venous extracorporeal CO2 removal (ECCO2R) might allow ultraprotective ventilation with lower tidal volume (VT) and plateau pressure (Pplat). This study investigated whether ECCO2R therapy could ...[more]

PMID: 33411146

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