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NK cell-based cancer immunotherapy: from basic biology to clinical development.

ABSTRACT: Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK receptors with target cells, independent of antigen processing and presentation. Due to relatively unsophisticated cues for activation, NK cell has gained significant attention in the field of cancer immunotherapy. Many efforts are emerging for developing and engineering NK cell-based cancer immunotherapy. In this review, we provide our current understandings of NK cell biology, ongoing pre-clinical and clinical development of NK cell-based therapies and discuss the progress, challenges, and future perspectives.

SUBMITTER: Liu S

PROVIDER: S-EPMC7788999 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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NK cell-based cancer immunotherapy: from basic biology to clinical development.

Liu Sizhe S Galat Vasiliy V Galat Yekaterina Y Lee Yoo Kyung Annie YKA Wainwright Derek D Wu Jennifer J

Journal of hematology & oncology 20210106 1

Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK receptors with target cells, independent of antigen processing and presentation. Due to relatively unsophisticated cues for activation, NK cell has gained significant attention in the field of cancer immunotherapy. Many efforts are emerging for devel ...[more]

PMID: 33407739

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