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Highly Regio- and Enantioselective Vicinal Dihalogenation of Allyl Amides.

ABSTRACT: We report a highly regio-, diastereo- and enantioselective vicinal dihalogenation of allyl amides. E- and Z-alkenes with both aryl and alkyl substituents were compatible with this chemistry. This is the result of exquisite catalyst controlled regioselectivity enabling use of electronically unbiased substrates. The reaction employs commercially available catalysts and halenium sources along with cheap inorganic halide salts to affect this transformation. A preliminary effort to extend this chemistry to heterodihalogenation is also presented.

SUBMITTER: Soltanzadeh B

PROVIDER: S-EPMC7790169 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Highly Regio- and Enantioselective Vicinal Dihalogenation of Allyl Amides.

Soltanzadeh Bardia B Jaganathan Arvind A Yi Yi Y Yi Hajoon H Staples Richard J RJ Borhan Babak B

Journal of the American Chemical Society 20170203 6

We report a highly regio-, diastereo- and enantioselective vicinal dihalogenation of allyl amides. E- and Z-alkenes with both aryl and alkyl substituents were compatible with this chemistry. This is the result of exquisite catalyst controlled regioselectivity enabling use of electronically unbiased substrates. The reaction employs commercially available catalysts and halenium sources along with cheap inorganic halide salts to affect this transformation. A preliminary effort to extend this chemis ...[more]

PMID: 28112919

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