Dataset Information

Personality dimensions of patients can change during the course of parkinson's disease.

ABSTRACT:

Background

Studies assessing personality dimensions by the "Temperament and Character Inventory" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations.

Methods

All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosurgery. Their results were compared to those of historical cohorts (a French normative population, a de novo PD population, and a PD population with motor fluctuations).

Results

Most personality dimensions of our 333 included PD patients with motor fluctuations who are candidates for DBS were different from those of the normative population and some were also different from those of the De Novo PD population, whereas they were similar to those of another population of PD patients with motor fluctuations.

Conclusions

During the course of PD, personality dimensions can change in parallel with the development of motor fluctuations, either due to the evolution of the disease and/or dopaminergic treatments.

SUBMITTER: Boussac M

PROVIDER: S-EPMC7790271 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Personality dimensions of patients can change during the course of parkinson's disease.

Boussac Mathilde M Arbus Christophe C Dupouy Julia J Harroch Estelle E Rousseau Vanessa V Croiset Aurélie A Ory-Magne Fabienne F Rascol Olivier O Moreau Caroline C Rolland Anne-Sophie AS Maltête David D Rouaud Tiphaine T Meyer Mylène M Drapier Sophie S Giordana Bruno B Anheim Mathieu M Hainque Elodie E Jarraya Béchir B Benatru Isabelle I Auzou Nicolas N Belamri Lhaouas L Tir Mélissa M Marques Ana-Raquel AR Thobois Stephane S Eusebio Alexandre A Corvol Jean Christophe JC Devos David D Brefel-Courbon Christine C

PloS one 20210107 1

<h4>Background</h4>Studies assessing personality dimensions by the "Temperament and Character Inventory" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations.<h4>Methods</h4>All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosur ...[more]

PMID: 33411732

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Project description:ImportanceChanges in behavior and personality are 1 criterion for the diagnosis of dementia. It is unclear, however, whether such changes begin before the clinical onset of the disease.ObjectiveTo determine whether increases in neuroticism, declines in conscientiousness, and changes in other personality traits occur before the onset of mild cognitive impairment or dementia.Design, setting, and participantsA cohort of 2046 community-dwelling older adults who volunteered to participate in the Baltimore Longitudinal Study of Aging were included. The study examined personality and clinical assessments obtained between 1980 and July 13, 2016, from participants with no cognitive impairment at first assessment who were followed up for as long as 36 years (mean [SD], 12.05 [9.54] years). The self-report personality scales were not considered during consensus diagnostic conferences.Main outcomes and measuresChange in self-rated personality traits assessed in the preclinical phase of Alzheimer disease and other dementias with the Revised NEO Personality Inventory, a 240-item questionnaire that assesses 30 facets, 6 for each of the 5 major dimensions: neuroticism, extraversion, openness, agreeableness, and conscientiousness.ResultsOf the?2046 participants, 931 [45.5%] were women; mean (SD) age at first assessment was 62.56 (14.63) years. During 24?569 person-years, mild cognitive impairment was diagnosed in 104 (5.1%) individuals, and all-cause dementia was diagnosed in 255 (12.5%) participants, including 194 (9.5%) with Alzheimer disease. Multilevel modeling that accounted for age, sex, race, and educational level found significant differences on the intercept of several traits: individuals who developed dementia scored higher on neuroticism (??=?2.83; 95% CI, 1.44 to 4.22; P?<?.001) and lower on conscientiousness (??=?-3.34; 95% CI, -4.93 to -1.75; P?<?.001) and extraversion (??=?-1.74; 95% CI, -3.23 to -0.25; P?=?.02). Change in personality (ie, slope), however, was not significantly different between the nonimpaired and the Alzheimer disease groups (eg, neuroticism: ??=?0.00; 95% CI, -0.08 to 0.08; P?=?.91; conscientiousness: ??=?-0.06; 95% CI, -0.16 to 0.04; P?=?.24). Slopes for individuals who developed mild cognitive impairment (eg, neuroticism: ??=?0.00; 95% CI, -0.12 to 0.12; P?=?.98; conscientiousness: ??=?-0.09; 95% CI, -0.23 to 0.05; P?=?.18) and all-cause dementia (eg, neuroticism: ??=?0.02; 95% CI, -0.06 to 0.10; P?=?.49; conscientiousness: ??=?-0.08; 95% CI, -0.16 to 0.00; P?=?.07) were also similar to those for nonimpaired participants.Conclusions and relevanceNo evidence for preclinical change in personality before the onset of mild cognitive impairment or dementia was identified. These findings provide evidence against the reverse causality hypothesis and strengthen evidence for personality traits as a risk factor for dementia.

Dataset Information

Personality dimensions of patients can change during the course of parkinson's disease.

Background

Methods

Results

Conclusions

Publications

Personality dimensions of patients can change during the course of parkinson's disease.

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