Ontology highlight
ABSTRACT:
SUBMITTER: Carcamo-Orive I
PROVIDER: S-EPMC7790417 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Carcamo-Orive Ivan I Henrion Marc Y R MYR Zhu Kuixi K Beckmann Noam D ND Cundiff Paige P Moein Sara S Zhang Zenan Z Alamprese Melissa M D'Souza Sunita L SL Wabitsch Martin M Schadt Eric E EE Quertermous Thomas T Knowles Joshua W JW Chang Rui R
PLoS computational biology 20201223 12
Insulin resistance (IR) precedes the development of type 2 diabetes (T2D) and increases cardiovascular disease risk. Although genome wide association studies (GWAS) have uncovered new loci associated with T2D, their contribution to explain the mechanisms leading to decreased insulin sensitivity has been very limited. Thus, new approaches are necessary to explore the genetic architecture of insulin resistance. To that end, we generated an iPSC library across the spectrum of insulin sensitivity in ...[more]