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Flipping the Switch from Inflammation to Cell Death.

ABSTRACT: Multiple research groups have demonstrated that caspase-8 (CASP8)-mediated gasdermin D (GSDMD) cleavage drives pyroptotic cell death. Here, we discuss a novel role for the enzymatically inactive homolog of CASP8, the long isoform of cellular FLICE-like inhibitory protein (cFLIPL), in the regulation of this process. Specifically, cFLIP-deficiency provides a model in which to study the mechanisms regulating CASP8-mediated activation of cell death and inflammatory signaling.

SUBMITTER: Muendlein HI

PROVIDER: S-EPMC7790434 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Flipping the Switch from Inflammation to Cell Death.

Muendlein Hayley I HI Poltorak Alexander A

Trends in immunology 20200701 8

Multiple research groups have demonstrated that caspase-8 (CASP8)-mediated gasdermin D (GSDMD) cleavage drives pyroptotic cell death. Here, we discuss a novel role for the enzymatically inactive homolog of CASP8, the long isoform of cellular FLICE-like inhibitory protein (cFLIP<sub>L</sub>), in the regulation of this process. Specifically, cFLIP-deficiency provides a model in which to study the mechanisms regulating CASP8-mediated activation of cell death and inflammatory signaling. ...[more]

PMID: 32622855

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