Ontology highlight
ABSTRACT:
SUBMITTER: Sakai S
PROVIDER: S-EPMC7790750 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Sakai Shunsuke S Kauffman Keith D KD Oh Sangmi S Nelson Christine E CE Barry Clifton E CE Barber Daniel L DL
Mucosal immunology 20200818 1
Mucosal-associated invariant T (MAIT) cells are potential targets of vaccination and host-directed therapeutics for tuberculosis, but the role of MAIT cells during Mycobacterium tuberculosis (Mtb) infection in vivo is not well understood. Here we find that following Mtb infection MAIT cells mount minimal responses, and MAIT cell-deficient MR1<sup>-/-</sup> mice display normal survival. Preinfection expansion of MAIT cells through 5-OP-RU vaccination fails to protect against subsequent Mtb challe ...[more]