Ontology highlight
ABSTRACT:
SUBMITTER: Tao W
PROVIDER: S-EPMC7791017 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Tao Wenyuan W Yu Linjie L Shu Shu S Liu Ying Y Zhuang Zi Z Xu Siyi S Bao Xinyu X Gu Yue Y Cai Fang F Song Weihong W Xu Yun Y Zhu Xiaolei X
Molecular therapy : the journal of the American Society of Gene Therapy 20200905 1
Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly, and the mechanisms of AD are not fully defined. MicroRNAs (miRNAs) have been shown to contribute to memory deficits in AD. In this study, we identified that miR-204-3p was downregulated in the hippocampus and plasma of 6-month-old APPswe/PS1dE9 (APP/PS1) mice. miR-204-3p overexpression attenuated memory and synaptic deficits in APP/PS1 mice. The amyloid levels and oxidative stress were decr ...[more]