Ontology highlight
ABSTRACT:
SUBMITTER: Hajek M
PROVIDER: S-EPMC7793113 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Hajek Michael M Biktasova Asel A Sewell Andrew A Gary Cyril C Cantalupo Paul P Anderson Karen S KS Yarbrough Wendell G WG Issaeva Natalia N Issaeva Natalia N
Cancers 20201223 1
High levels of DNA methylation at CpG loci are associated with transcriptional repression of tumor suppressor genes and dysregulation of DNA repair genes. Human papilloma virus (HPV)-associated head and neck squamous cell carcinomas (HNSCC) have high levels of DNA methylation and methylation has been associated with dampening of an innate immune response in virally infected cells. We have been exploring demethylation as a potential treatment in HPV+ HNSCC and recently reported results of a windo ...[more]