Ontology highlight
ABSTRACT:
SUBMITTER: Zhang A
PROVIDER: S-EPMC7793280 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Zhang Albert A Guan Ziqiang Z Ockerman Kyle K Dong Pengyuan P Guo Jiansheng J Wang Zhiping Z Yan Dong D
PLoS biology 20201228 12
Coordination of cell growth is essential for the development of the brain, but the molecular mechanisms underlying the regulation of glial and neuronal size are poorly understood. To investigate the mechanisms involved in glial size regulation, we used Caenorhabditis elegans amphid sheath (AMsh) glia as a model and show that a conserved cis-Golgi membrane protein eas-1/GOLT1B negatively regulates glial growth. We found that eas-1 inhibits a conserved E3 ubiquitin ligase rnf-145/RNF145, which, in ...[more]