Ontology highlight
ABSTRACT:
SUBMITTER: Behary J
PROVIDER: S-EPMC7794332 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Behary Jason J Amorim Nadia N Jiang Xiao-Tao XT Raposo Anita A Gong Lan L McGovern Emily E Ibrahim Ragy R Chu Francis F Stephens Carlie C Jebeili Hazem H Fragomeli Vincenzo V Koay Yen Chin YC Jackson Miriam M O'Sullivan John J Weltman Martin M McCaughan Geoffrey G El-Omar Emad E Zekry Amany A
Nature communications 20210108 1
The gut microbiota is reported to modulate the immune response in hepatocellular carcinoma (HCC). Here, we employ metagenomic and metabolomic studies to characterise gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) related cirrhosis, with or without HCC, and evaluate its effect on the peripheral immune response in an ex vivo model. We find that dysbiosis characterises the microbiota of patients with NAFLD-cirrhosis, with compositional and functional shifts occurring with ...[more]