Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7794439 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wang Xu X Hu Li-Peng LP Qin Wei-Ting WT Yang Qin Q Chen De-Yu DY Li Qing Q Zhou Kai-Xia KX Huang Pei-Qi PQ Xu Chun-Jie CJ Li Jun J Yao Lin-Li LL Wang Ya-Hui YH Tian Guang-Ang GA Yang Jian-Yu JY Yang Min-Wei MW Liu De-Jun DJ Sun Yong-Wei YW Jiang Shu-Heng SH Zhang Xue-Li XL Zhang Zhi-Gang ZG
Nature communications 20210108 1
The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specific phenotypes, functions and regulatory mechanisms of neutrophils in PDAC liver metastases remain unknown. Here, we show that a subset of P2RX1-negative neutrophils accumulate in clinical and murine PD ...[more]