Ontology highlight
ABSTRACT:
SUBMITTER: Bertocchi I
PROVIDER: S-EPMC7794508 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Bertocchi Ilaria I Eltokhi Ahmed A Rozov Andrey A Chi Vivan Nguyễn VN Jensen Vidar V Bus Thorsten T Pawlak Verena V Serafino Marta M Sonntag Hannah H Yang Boyi B Burnashev Nail N Li Shi-Bin SB Obenhaus Horst A HA Both Martin M Niewoehner Burkhard B Single Frank N FN Briese Michael M Boerner Thomas T Gass Peter P Rawlins John Nick P JNP Köhr Georg G Bannerman David M DM Sprengel Rolf R
Communications biology 20210108 1
The NMDA receptor-mediated Ca<sup>2+</sup> signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations of this coincidence detection provoked complex clinical phenotypes, ranging from reduced muscle strength to epileptic seizures and intellectual disability. By using our gene-targeted mouse line (Grin2a<sup>N615S</sup>), we show that voltage-independent glutamate-ga ...[more]