Ontology highlight
ABSTRACT:
SUBMITTER: Huang R
PROVIDER: S-EPMC6778234 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20190917 40
Action potential-induced vesicular exocytosis is considered exclusively Ca<sup>2+</sup> dependent in Katz's Ca<sup>2+</sup> hypothesis on synaptic transmission. This long-standing concept gets an exception following the discovery of Ca<sup>2+</sup>-independent but voltage-dependent secretion (CiVDS) and its molecular mechanisms in dorsal root ganglion sensory neurons. However, whether CiVDS presents only in sensory cells remains elusive. Here, by combining multiple independent recordings, we rep ...[more]