Ontology highlight
ABSTRACT:
SUBMITTER: Grijalvo S
PROVIDER: S-EPMC7796380 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20201224 1
Two G-quadruplex forming oligonucleotides [d(TG<sub>4</sub>T)<sub>4</sub> and d(TG<sub>6</sub>T)<sub>4</sub>] were selected as two tetramolecular quadruplex nanostructures because of their demonstrated ability to be modified with hydrophobic molecules. This allowed us to synthesize two series of G-quadruplex conjugates that differed in the number of G-tetrads, as well as in the terminal position of the lipid modification. Both solution and solid-phase syntheses were carried out to yield the corr ...[more]