Immunodynamics of explanted human tumors for immuno-oncology.
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ABSTRACT:
SUBMITTER: Dubuisson A
PROVIDER: S-EPMC7799366 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Immunodynamics of explanted human tumors for immuno-oncology.
Dubuisson Agathe A Fahrner Jean-Eudes JE Goubet Anne-Gaëlle AG Terrisse Safae S Voisin Nicolas N Bayard Charles C Lofek Sebastien S Drubay Damien D Bredel Delphine D Mouraud Séverine S Susini Sandrine S Cogdill Alexandria A Rebuffet Lucas L Ballot Elise E Jacquelot Nicolas N Thomas de Montpreville Vincent V Casiraghi Odile O Radulescu Camélia C Ferlicot Sophie S Figueroa David J DJ Yadavilli Sapna S Waight Jeremy D JD Ballas Marc M Hoos Axel A Condamine Thomas T Parier Bastien B Gaudillat Christophe C Routy Bertrand B Ghiringhelli François F Derosa Lisa L Breuskin Ingrid I Rouanne Mathieu M André Fabrice F Lebacle Cédric C Baumert Hervé H Wislez Marie M Fadel Elie E Cremer Isabelle I Albiges Laurence L Geoerger Birgit B Scoazec Jean-Yves JY Loriot Yohann Y Kroemer Guido G Marabelle Aurélien A Bonvalet Mélodie M Zitvogel Laurence L
EMBO molecular medicine 20201229 1
Decision making in immuno-oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno-assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in ...[more]
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