Dataset Information

The complete mitochondrial genome of White-cheeked macaque (Macaca leucogenys).

ABSTRACT: White-cheeked macaque is a newly described species in genus Macaca. Here, the complete mitochondrial genome was firstly determined, which was deposited in Genbank with accession number KU564271. The length of the mitogenome is 16,494 base pairs (bp). It includes 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes and a control region. We used 12 mitochondrion genes of 15 species to constructed phylogenetic tree with three methods. The study will provide useful data for further studies on phylogenetic relationships as well as population structure, biodiversity conservation and conservation genetics.

SUBMITTER: Hou W

PROVIDER: S-EPMC7799460 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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The complete mitochondrial genome of White-cheeked macaque (<i>Macaca leucogenys</i>).

Hou Wei W Liu Sanxu S Jiang Juan J Fan Zhenxin Z Fan Pengfei P Li Jing J

Mitochondrial DNA. Part B, Resources 20160620 1

White-cheeked macaque is a newly described species in genus <i>Macaca</i>. Here, the complete mitochondrial genome was firstly determined, which was deposited in Genbank with accession number KU564271. The length of the mitogenome is 16,494 base pairs (bp). It includes 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes and a control region. We used 12 mitochondrion genes of 15 species to constructed phylogenetic tree with three methods. The study will pr ...[more]

PMID: 33473488

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Project description:Macaques are the most widely distributed nonhuman primates and used as animal models in biomedical research. The availability of full-genome sequences from them would be essential to both biomedical and primate evolutionary studies. Previous studies have reported whole-genome sequences from rhesus macaque (Macaca mulatta) and cynomolgus macaque (M. fascicularis, CE), both of which belong to the fascicularis group. Here, we present a 37-fold coverage genome sequence of the Tibetan macaque (M. thibetana; TM). TM is an endemic species to China belonging to the sinica group. On the basis of mapping to the rhesus macaque genome, we identified approximately 11.9 million single-nucleotide variants), of which 3.9 million were TM specific, as assessed by comparison two Chinese rhesus macaques (CR) and two CE genomes. Some genes carried TM-specific homozygous nonsynonymous variants (TSHNVs), which were scored as deleterious in human by both PolyPhen-2 and SIFT (Sorting Tolerant From Intolerant) and were enriched in the eye disease genes. In total, 273 immune response and disease-related genes carried at least one TSHNV. The heterozygosity rates of two CRs (0.002617 and 0.002612) and two CEs (0.003004 and 0.003179) were approximately three times higher than that of TM (0.000898). Polymerase chain reaction resequencing of 18 TM individuals showed that 29 TSHNVs exhibited high allele frequencies, thus confirming their low heterozygosity. Genome-wide genetic divergence analysis demonstrated that TM was more closely related to CR than to CE. We further detected unusual low divergence regions between TM and CR. In addition, after applying statistical criteria to detect putative introgression regions (PIRs) in the TM genome, up to 239,620 kb PIRs (8.84% of the genome) were identified. Given that TM and CR have overlapping geographical distributions, had the same refuge during the Middle Pleistocene, and show similar mating behaviors, it is highly likely that there was an ancient introgression event between them. Moreover, demographic inferences revealed that TM exhibited a similar demographic history as other macaques until 0.5 Ma, but then it maintained a lower effective population size until present time. Our study has provided new insight into the macaque evolutionary history, confirming hybridization events between macaque species groups based on genome-wide data.

Dataset Information

The complete mitochondrial genome of White-cheeked macaque (Macaca leucogenys).

Publications

The complete mitochondrial genome of White-cheeked macaque (<i>Macaca leucogenys</i>).

Similar Datasets

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