Dataset Information

Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications.

ABSTRACT:

Introduction

Chronic idiopathic constipation (CIC) is a prevalent functional gastrointestinal disorder diagnosed based on patient-reported symptoms and the absence of structural gastrointestinal abnormalities. Individuals with CIC typically institute dietary changes and use stool softeners or over-the-counter (OTC) laxatives, possibly at the direction of a healthcare provider, before prescription medications for CIC are initiated. Although highly prevalent, there is limited information regarding CIC patient experiences with OTC medications.

Methods

This post-hoc analysis used patient-reported data from a questionnaire administered during patient screening for a prospective linaclotide Phase 3b clinical trial in patients with CIC (N = 1482 screened). The questionnaire asked patients to report their experiences with OTC CIC medications over the preceding 6 months.

Results

Among patients with screening responses (N = 1423), most were female (85%) and white (66%), with a mean age of 48.9 years. A high proportion of patients had used one or more OTC medications (70% had ?1 OTC; 19% had ?3 OTCs), with the majority being bisacodyl (33%) and polyethylene glycol (30%). The most commonly cited reason for stopping an OTC medication was insufficient symptom relief (17-40%). The majority of patients taking OTC medications reported no or little satisfaction with the medication's effect on their constipation (62%) and CIC-specific abdominal symptoms (78%). Many patients had little to no confidence in bowel movement (BM) frequency after taking OTC medications and their confidence in their ability to predict BM timing was also low (49-81% not at all confident).

Conclusions

Treatment effects on individual CIC symptoms, predictability of bowel habits, and satisfaction with treatment are all important factors for healthcare providers and patients to consider when establishing an effective treatment regimen for CIC.

Trial registration number

NCT01642914.

SUBMITTER: Lacy BE

PROVIDER: S-EPMC7799845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications.

Lacy Brian E BE Shea Elizabeth P EP Manuel Machelle M Abel Jessica L JL Jiang Hancheng H Taylor Douglas C A DCA

PloS one 20210111 1

<h4>Introduction</h4>Chronic idiopathic constipation (CIC) is a prevalent functional gastrointestinal disorder diagnosed based on patient-reported symptoms and the absence of structural gastrointestinal abnormalities. Individuals with CIC typically institute dietary changes and use stool softeners or over-the-counter (OTC) laxatives, possibly at the direction of a healthcare provider, before prescription medications for CIC are initiated. Although highly prevalent, there is limited information r ...[more]

PMID: 33428631

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Dataset Information

Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications.

Introduction

Methods

Results

Conclusions

Trial registration number

Publications

Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications.

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