Ontology highlight
ABSTRACT:
SUBMITTER: Dang PH
PROVIDER: S-EPMC7801053 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Evidence-based complementary and alternative medicine : eCAM 20210104
From a CHCl<sub>3</sub>-soluble extract of the stems of <i>Semecarpus caudata</i> (Anacardiaceae), two new diarylalkanoids, semedienone (<b>1</b>) and semetrienone (<b>2</b>), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC<sub>50</sub> values of 0.033 and 0.11 <i>μ</i>M, respectively. Docking studies of <b>1</b> and <b>2</b> with <i>oxy</i>-tyrosinase were carried out to ana ...[more]