Ontology highlight
ABSTRACT:
SUBMITTER: Haudecoeur R
PROVIDER: S-EPMC5238473 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20161117 1
With the aim to develop effective and selective human tyrosinase inhibitors, we investigated aurone derivatives whose B-ring was replaced by a non-oxidizable 2-hydroxypyridine-<i>N</i>-oxide (HOPNO) moiety. These aurones were synthesized and evaluated as inhibitors of purified human tyrosinase. Excellent inhibition activity was revealed and rationalized by theoretical calculations. The aurone backbone was especially found to play a crucial role, as the HOPNO moiety alone provided very modest act ...[more]