Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC7801405 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Yang Jun J Zhu Hanwen H Zhang Tianlong T Ding Jianping J
Cell discovery 20210112 1
D-2-hydroxyglutarate dehydrogenase (D-2-HGDH) catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) into 2-oxoglutarate, and genetic D-2-HGDH deficiency leads to abnormal accumulation of D-2-HG which causes type I D-2-hydroxyglutaric aciduria and is associated with diffuse large B-cell lymphoma. This work reports the crystal structures of human D-2-HGDH in apo form and in complexes with D-2-HG, D-malate, D-lactate, L-2-HG, and 2-oxoglutarate, respectively. D-2-HGDH comprises a FAD-binding dom ...[more]