Ontology highlight
ABSTRACT:
SUBMITTER: Juraszek J
PROVIDER: S-EPMC7801441 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210111 1
The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends to prematurely refold to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yields. To support ongoing vaccine development efforts, we report the structure-based design of soluble S trimers with increased yields and stabilities, based on introduction of single point mutations ...[more]