Ontology highlight
ABSTRACT:
SUBMITTER: Takayama J
PROVIDER: S-EPMC7801658 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210111 1
The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using > 100× Pacific Biosciences long reads and Bionano Genomics optical maps per sample. We integrate the genomes using the major allele for consensus and anchor the scaffolds using gene ...[more]