Unknown

Dataset Information

0

Decreased expression of METTL14 predicts poor prognosis and construction of a prognostic signature for clear cell renal cell carcinoma.


ABSTRACT:

Background

METTL14, as one of N6-methyladenosine (m6A) related genes, has been found to be associated with promoting tumorigenesis in different types of cancers. This study was aimed to investigate the prognostic value of METTL14 in clear cell renal cell carcinoma (ccRCC).

Methods

We collected ccRCC patients' clinicopathological parameters information and 13 m6A related genes expression from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analyses were conducted to investigate whether METTL14 could serve as an independent factor correlated with overall survival (OS). Gene Set Enrichment Analysis (GSEA) was carried out to identify METTL14-related signaling pathways. Moreover, a risk score (RS) was calculated to predict the prognosis of ccRCC. Quantitative real-time PCR (qRT-PCR) was also utilized to verify the expression of METTL14 in clinical specimens.

Results

Differently expressed m6A related genes were identified between ccRCC tissues and normal tissues. Therein, METTL14 was lowly expressed in ccRCC tissues and verified by qRT-PCR (all p?ConclusionsOur results indicated that METTL14 could serve as a favorable prognostic factor for ccRCC. Moreover, this study also provided a prognostic signature to predict prognosis of ccRCC and identified METTL14-related signaling pathways.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7802286 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Decreased expression of METTL14 predicts poor prognosis and construction of a prognostic signature for clear cell renal cell carcinoma.

Wang Yi Y   Cong Rong R   Liu Shouyong S   Zhu Bingye B   Wang Xing X   Xing Qianwei Q  

Cancer cell international 20210111 1


<h4>Background</h4>METTL14, as one of N6-methyladenosine (m6A) related genes, has been found to be associated with promoting tumorigenesis in different types of cancers. This study was aimed to investigate the prognostic value of METTL14 in clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>We collected ccRCC patients' clinicopathological parameters information and 13 m6A related genes expression from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analys  ...[more]

Similar Datasets

| S-EPMC8791850 | biostudies-literature
| S-EPMC5529904 | biostudies-other
| S-EPMC7539765 | biostudies-literature
| S-EPMC8454526 | biostudies-literature
| S-EPMC6778431 | biostudies-literature
| S-EPMC7333652 | biostudies-literature
| S-EPMC5351589 | biostudies-literature
| S-EPMC10503121 | biostudies-literature
| S-EPMC4619904 | biostudies-literature
| S-EPMC4998678 | biostudies-literature