Ontology highlight
ABSTRACT:
SUBMITTER: Strinkovsky L
PROVIDER: S-EPMC7803374 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Strinkovsky Lior L Havkin Evgeny E Shalom-Feuerstein Ruby R Savir Yonatan Y
eLife 20210112
Homeostasis in adult tissues relies on the replication dynamics of stem cells, their progenitors and the spatial balance between them. This spatial and kinetic coordination is crucial to the successful maintenance of tissue size and its replenishment with new cells. However, our understanding of the role of cellular replicative lifespan and spatial correlation between cells in shaping tissue integrity is still lacking. We developed a mathematical model for the stochastic spatial dynamics that un ...[more]