Ontology highlight
ABSTRACT:
SUBMITTER: Sato M
PROVIDER: S-EPMC7803739 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Sato Miku M Harada-Shoji Narumi N Toyohara Takafumi T Soga Tomoyoshi T Itoh Masatoshi M Miyashita Minoru M Tada Hiroshi H Amari Masakazu M Anzai Naohiko N Furumoto Shozo S Abe Takaaki T Suzuki Takashi T Ishida Takanori T Sasano Hironobu H
Scientific reports 20210112 1
<sup>18</sup>F-FDG PET/CT has been used as an indicator of chemotherapy effects, but cancer cells can remain even when no FDG uptake is detected, indicating the importance of exploring other metabolomic pathways. Therefore, we explored the amino acid metabolism, including L-type amino acid transporter-1 (LAT1), in breast cancer tissues and clarified the role of LAT1 in therapeutic resistance and clinical outcomes of patients. We evaluated LAT1 expression before and after neoadjuvant chemotherapy ...[more]