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Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.

ABSTRACT: The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.

SUBMITTER: Hall AJ

PROVIDER: S-EPMC7804430 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.

Hall Andrew J AJ Robertson Amy G AG Hill Leila R LR Rendina Louis M LM

Scientific reports 20210112 1

The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents. ...[more]

PMID: 33436690

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